Work published by a number of groups including ours in last few years showed that EBI2 and key enzymes in producing 7α, 25-OHC were highly regulated during inflammation, and might play key roles in pathogenesis of certain human diseases such as to inflammation and autoimmune diseases, neurodegenerative disease, cardiovascular diseases, cancers, as well as metabolic diseases such as diabetes, obesity, and dyslipidemia. This evidence concerns the gene GPR183 and metabolic disease.