IL-1β levels are increased in alcoholics, as well as animal models of chronic alcohol exposure (Valles et al., 2004; Qin et al., 2008; Lippai et al., 2013a,b), and intracerebroventricular administrations of IL-1β potentiate alcohol withdrawal-induced anxiety (Breese et al., 2008). Here, IL1B is linked to Anxiety.