As far as the 5-HT control of generalized ASs is concerned, most of the limited available evidence has been obtained in WAG/Rij rats, with 5-HT1A-, 5-HT2C-, and 5-HT7-Rs appearing as the most critical for the expression of this form of epilepsy (Bagdy et al., 2007). The gene discussed is HTR1A; the disease is epilepsy.