Compelling evidence for the involvement of 5-HT1A- and 5-HT7-Rs in epilepsy and depression has been described, therefore it is possible to infer that agonists at these receptors might have both antiepileptic and antidepressant activity with also cognitive enhancer efficacy (Orban et al., 2013). The gene discussed is HTR1A; the disease is depressive symptom measurement.