ERBB2 and central nervous system cancer: For example, the Na+/HCO3− contransporter is upregulated by human epidermal growth factor receptor 2 (HER2) signaling in breast cancer cells (Gorbatenko et al., 2014), and NKCC modulates glioma cell migration through regulation of focal adhesions and cell volume (Garzon-Muvdi et al., 2012).