Expression levels of KV10.1 (EAG1, voltage gated eag related subfamily H, member 1) are lower in glioblastoma multiforme and in malignant brain tumors than in normal brain tissue, and expression of the EAG1 channel is inversely related to malignancy of the tumor (Patt et al., 2004). The gene discussed is KCNH1; the disease is glioblastoma.