SLC1A2 and major depressive disorder: In situ hybridization data from animal models of MDD also show a reduction in the expression of the GLT-1 in the hippocampus and cerebral cortex (Zink et al., 2010), suggesting a dysfunction in glutamate reuptake, glutamine synthesis and in the glutamate-GABA shunt, possibly underlying the pathology of MDD (Rajkowska and Stockmeier, 2013; Verkhratsky et al., 2014).