TRIM32 has been linked to several human diseases including limb–girdle muscular dystrophy type 2H (Frosk et al., 2002, 2005; Kudryashova et al., 2005, 2012), Bardet–Biedl syndrome (Chiang et al., 2006), cancer (Horn et al., 2004; Kano et al., 2008), autism spectrum disorder (Lionel et al., 2011, 2014), depression (Ruan et al., 2014), Alzheimer's disease (Yokota et al., 2006), obsessive compulsive disorder (Lionel et al., 2014), anxiety (Lionel et al., 2014), and attention deficit hyperactivity disorder (Lionel et al., 2011, 2014). This evidence concerns the gene TRIM32 and major depressive disorder.