Though TDP-43 aggregation is a typical hallmark of many other neurodegenerative disorders, such as Alzheimer's disease, Guam Parkinsonism dementia complex, and Lewy body disease (Dickson, 2008), its impact on FTD in influencing the regulation of the network should not be underestimated. Here, TARDBP is linked to early-onset autosomal dominant Alzheimer disease.