Since TDP-43 is capable to bind through its C-terminal region the hnRNP proteins (Buratti et al., 2005), the accumulation of these ribonucleoprotein on the RNA foci could indirectly influence TDP-43 function, creating a possible link of interaction between these two factors involved in FTD and ALS (Gendron et al., 2013). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.