FUS inclusions are not only observed in presence of FUS mutations, as they were found in patients with different or unknown genetic defects such as sporadic ALS, ALS/dementia or FTLD (with or without progranulin mutations), FUS or TDP43 mutation-linked familial ALS, SOD1-negative familial ALS. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.