VCP and amyotrophic lateral sclerosis: VCP has been detected in a few inclusions of neurodegenerative diseases such as senile plaques in Alzheimer's disease, Lewy bodies in Parkinson's disease, neuronal intranuclear inclusions in CAG/polyglutamine diseases and ubiquitin-positive inclusions in ALS (Hirabayashi et al., 2001; Mizuno et al., 2003; Ishigaki et al., 2004).