Though TDP-43 aggregation is a typical hallmark of many other neurodegenerative disorders, such as Alzheimer's disease, Guam Parkinsonism dementia complex, and Lewy body disease (Dickson, 2008), its impact on FTD in influencing the regulation of the network should not be underestimated. The gene discussed is TARDBP; the disease is Lewy body dementia.