In this study, we have identified that adaptors SKAP55 (src kinase-associated protein of 55 kDa; also termed SKAP1/src kinase-associated protein-1) and ADAP (adhesion and degranulation promoting adaptor protein; also known as Fyb/Fyn binding protein; or SLAP-130/SLP-76-associated protein of 130 kDa) are located at the killing synapses between CD8+ CTLs and tumor cells. This evidence concerns the gene SKAP1 and neoplasm.