Neutralization of IL-6 activity influenced only at priming of donor CD4+ T cells with DCs, but did not affect CD8+ T-cell activation, because the DCs used in this vaccination were only pulsed with OVA-IIp, and tumour-specific CD8+ T cells should be exposed to antigen only after the challenge with MCA-OVA (Fig. 7b). Here, CD4 is linked to neoplasm.