In female patients, logistic regression analysis of LEAD showed that age (OR, 1.235; 95%CI (1.133-1.347); P < 0.001), hypertension (OR, 3.231; 95%CI 1.102-9.470; P = 0.033), FGF21 (OR, 1.106; 95%CI 1.008-1.223; P = 0.028) were independent impact factors for LEAD. The gene discussed is FGF21; the disease is Hypertension.