MECOM and myeloproliferative disorder: The most significant SNPs are rs12339666, which tags the JAK2 46/1 haplotype, and rs2201862, which is in a non-coding region proximal to MECOM. Of the three SNPs with moderate association, two are within or close to genes of potential functional relevance to MPN: the intergenic region between HBS1L and MYB and an intronic SNP in TERT, which has recently been associated with MPN in an independent study11, as well as several other malignancies.