For almost two decades, researchers have relied on a classic experimental model of allergic asthma in which mice are systemically sensitized to a foreign antigen (that is, OVA) to induce the production of OVA-specific TH2 cells and OVA-specific IgE antibodies.71 Subsequent exposures to aerosolized OVA results in rapid mass infiltration of TH2 cells in the airways, increased mucus production and development of airway hyper-responsiveness. Here, IGHE is linked to allergic asthma.