PCGEM1 and Familial prostate cancer: The scaffolding lncRNAs prostate cancer associated noncoding RNA 1 (PRNCR1) and prostate-specific transcript 1 (PCGEM1) have previously been reported to play a role in transcription of androgen receptor target genes in the androgen-resistant prostate cancer cell lines CWR22Rv1 and LNCaP-cds1/2 via a chromatin-looping mechanism involving the androgen receptor [105].