Only one of them, located in an intronic region of the Tf gene (SNP rs3811647), was associated with iron deficiency and affected transcription [20], while the others appear to have compensating effects, particularly the very well-known Cys282Tyr substitution in HFE, suggesting that this genetic factor that is characteristic of iron overload protects from iron deficiency anemia. This evidence concerns the gene TF and anemia.