PDGFD and neoplasm: In order to explore if Cox-2 inhibition influences known mediators involved in CAF recruitment into tumor tissues we quantified mRNA expression of TGFβ, interleukin 1β (IL1β), C-X-C motif chemokine 12 (CXCL12) also called SDF-1 (stromal cell-derived factor 1), and platelet derived growth factor D (PDGF-D) [38, 46, 47] in tumors treated with ASA and sunitinib.