Similar with I-BET762, I-BET151 also inhibits myeloma cell proliferation through inducing apoptosis and exerting strong anti-proliferative effect in vitro and in vivo through transcriptional repression of MYC and MYC-dependent programs by abrogating recruitment to transcriptional activator PTEFb [77]. The gene discussed is MYC; the disease is plasma cell myeloma.