HOXA9 and acute myeloid leukemia: PFI-1 and JQ1 dissociate BRD4 from HOXA9 and promotes differentiation, as a marker of poor prognosis in patients with acute myeloid leukemia [85] and overexpression of HOXA9 leads to expansion of hematopoietic stem cells in bone marrow cells and development of leukemia in mice [84, 85].