Using the Exomechip data available for RA, SLE and IBD, we found no additional TYK2 variants associated at P<0.05, in either the disease-specific analyses or a diseases-combined analysis (based on the hypothesis that independent genetic variants contribute to susceptibility in all three autoimmune diseases combined) (S2 Fig). The gene discussed is TYK2; the disease is systemic lupus erythematosus.