TYK2 and systemic lupus erythematosus: In SLE, the reported association is with the common TYK2 missense variant V362F predicted to be benign (rs2304256, MAF = 23%, OR = 0.70) [35]; in IBD, the reported association is with the TYK2 variant I684S (OR = 1.12) [36], which we demonstrate as protecting against RA.