TYK2 and rheumatoid arthritis: In the PheWAS testing the association between the TYK2 variants and the 502 common binary phenotypes (phenotype frequency>1%), we only observed a significant association (P<1x10-4) between the P1104A variant and RA (OR = 0.65, PMETA = 2.3x10-5), with an effect size consistent to the effect size observed in the Immunochip RA case-control cohort (Fig 5A) [2].