Genetic variation in the 19p32/TYK2-ICAM locus has also been associated with several other autoimmune diseases, including psoriasis, multiple sclerosis (MS), Type 1 diabetes (T1D), Crohn’s disease (CD), ulcerative colitis, and systemic lupus erythematosus (SLE) [35–42]. This evidence concerns the gene TYK2 and Crohn disease.