TYK2 and rheumatoid arthritis: In the current study, we performed a detailed analysis of the 19p32/TYK2-ICAM locus to comprehensively investigate the contribution of common and rare protein-coding variants to RA susceptibility using 1) dense genotyping of the locus with the Immunochip and Exomechip genotyping platforms and 2) exon sequencing of all 11 genes within this locus.