Using this platform, we screened a library of Food and Drug Administration (FDA) and foreign regulatory agency-approved drugs, and identified that perhexiline, an anti-anginal drug that inhibits mitochondrial carnitine palmitoyltransferase I (CPT-1) [19], promotes HER3 internalization and downregulation, inhibits signaling downstream of HER3, and inhibits cancer cell proliferation in vitro and in vivo. The gene discussed is ERBB3; the disease is cancer.