In contrast to studies reported with mice, our studies in human MSC show that ΔNp63α and ΔNp63γ increased osterix and decreased VDR. Another report, describing overexpressing p63γ in H1299 and Hela cells, and TAp63γ in an osteosarcoma cell line (SaoS2), also demonstrated a p63γ-induced increase in VDR [27]. The gene discussed is SP7; the disease is osteosarcoma.