Our findings, showing that this residue is phosphorylated in dependence on the TNF-α/IKKβ pathway in breast cancer cells, together with the fact that ATG2B is one of the major regulators of the autophagosome formation and distribution of lipid droplets14, suggest a novel IKKβ-dependent regulatory step in these processes under physiological or pathophysiological conditions. This evidence concerns the gene ATG2B and breast cancer.