IL1B and obesity due to melanocortin 4 receptor deficiency: Given the emerging link between ER stress-induced inflammasome activation and metabolic diseases such as obesity or type 2 diabetes, we hypothesise that ER stress is also increased in adipose tissue from obese pregnant women or women with GDM and that it mediates inflammasome activation leading to the release of IL-1 that underlies the development of insulin resistance evident in these conditions [7].