TIMP1 and chronic obstructive pulmonary disease: In a corresponding model, TIMP-1 was associated with increasing age in both non-COPD and COPD (Beta: 0.104, p = 0.002 and 0.102, p = 0.014), while in non-COPD only associated with productive cough and decreasing pack years (Beta: 0.065, p = 0.050 and −0.072, p = 0.034 respectively).