The intrinsically disordered proline-rich region plays an important structural role: it serves as a potential site for protein–protein interactions and as a linker region that projects the transactivation domain away from the central DNA-Binding Domain–DNA complex to push out and interact more efficiently with transcriptional coactivators and interestingly contains the most common p53 polymorphism, which has been associated with different cancer risks. This evidence concerns the gene TP53 and cancer.