This result is interesting in the context of a recent study by Beiko and colleagues which found that complete resection of CE tumour was associated with a survival advantage in patients with IDH1-positive but not IDH1-negative type tumours.[29] Thus, in IDH1-positive tumours, CE may represent a focus of transformation that is both prognostic and represents a target for surgical resection. Here, IDH1 is linked to neoplasm.