IDH1 and neoplasm: Relative to IDH1-R132H negative tumours, IDH1-R132H positive tumours demonstrated a significantly higher minimum ADC (1.115 x 10-3 ± 0.326 x 103 mm2/sec vs. 0.838 x 10-3 ± 0.266 x 103 mm2/sec; p = 0.016) (Fig 1C and 1D).