AKT1 and diffuse large B-cell lymphoma: We have demonstrated that treatment of DLBCL with EtOH suppressed mTORC1 activity in a dose dependent manner with concomitant augmentation of AKT phosphorylation at both Thr308 and Ser473, whereas the dual mTORC1/2 inhibitor INK128 completely abrogated AKT phosphorylation at these sites.