RPS6KB1 and diffuse large B-cell lymphoma: Exposure to either EtOH or INK128 inhibited the mTORC1 signaling pathway, as indicated by a dose-dependent reduction in the phosphorylation of mTOR on Ser2448 and its downstream molecules in both DLBCL cell lines (SUDHL-2 and SUDHL-4): p70S6K on Thr389, a direct target of mTORC1; RPS6 on Ser235/236, a substrate of p70S6K; and 4E-BP1 on Thr36/45 (Figure 1A and Additional file 1: Figure S1).