Importantly, among the top genes significantly changed consistently in both lymphoma cell lines, we found numerous genes involved in cellular functions, such as AKT/mTOR signaling and protein synthesis (eg. FKBP4, FKBP11, YWHAZ, MARS), cell cycle (eg. CDC25A, CDC42), proliferation and apoptosis (eg. TCL1A, TCL1B, LYN, CD27) (Figure 4B and Additional file 3: Table S1). The gene discussed is CD27; the disease is lymphoma.