In IEC preparations from Ifnlr1-/- mice that are highly susceptible to reovirus infection, induction of the Ifnl2/3 genes was nearly 100-fold higher than in infected wild-type mice, whereas type I IFN genes were not expressed at enhanced rates at this early time point (Fig 5C). The gene discussed is IFNL2; the disease is Reoviridae infectious disease.