Our findings, in agreement with other reports [40, 41], demonstrate that swim stress does not markedly alter alcohol two-bottle free-choice drinking in WT C57BL/6J mice, but suggest that intact relaxin-3/RXFP3 signalling may promote the maintenance of alcohol preference to relieve aversive states associated with acute and persistent anxiety produced by repeated stress exposure. Here, RXFP3 is linked to Anxiety.