Notably, both the presence of PD (probing depth≧4mm) and Pg was more enriched in the disease progression group (non-RA→RA) compared with non-RA (non-RA→non RA) patients (92.3% vs 55.2%, p = 0.04 for PD (probing depth≧4mm) and 61.5% vs 40.0%, p = 0.04 for Pg) (Table 5). Here, JUP is linked to rheumatoid arthritis.