Several groups have demonstrated phenotypes from keratinocytes derived from induced-pluripotent stem cells (iPSCs) from patients with genetic skin diseases including genes expressed in our gene signature: type VII collagen (Col7)-deficient recessive dystrophic epidermolysis bullosa (RDEB) [58, 61], laminin, beta 3 gene-deficient junctional epidermolysis bullosa (JEB) [60] and p63 mutant ectodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome [81]. The gene discussed is PSMB3; the disease is cleft lip.