In vivo, the minor variation of FADS1 may increase the levels of AA(derived from n-6 fatty acid LA), precursor of important proinflammatory molecules such as eicosanoids, which might induce a proinflammatory response linking to the progression of CAD [25], while EPA derived from n-3 fatty acid ALA presents anti- inflammatory effect. The gene discussed is FADS1; the disease is coronary artery disorder.