It is necessary to investigate the effects of linkers of different lengths, solubility, lipophilicity, and flexibility on the in vitro and in vivo behaviors of the dual integrin αvβ3 and GRPR targeted peptide to make it possible to bind to both receptors simultaneously, which may result in enhanced targeting efficacy and higher uptake of 99mTc-RGD-BBN by the tumor. The gene discussed is GRPR; the disease is neoplasm.