When we stratified our BC series by molecular subtypes, the association between Cdx2 polymorphism and VDR expression is maintained only in HS and TN (p = 0.008 and p = 0.003, respectively), but not in LA and LB (p>0.05) tumours characterized by ER positivity highlighting the influence of the receptor in this relationship (Fig 8). This evidence concerns the gene ESR1 and neoplasm.