Some of the canonical pathways that are different between odontoblasts and pre-secretory ameloblasts include—Intrinsic Prothrombin Activation Pathway, Hepatic Fibrosis / Hepatic Stellate Cell Activation, Atherosclerosis Signaling, Phospholipase C signaling, ERK5 signaling and Sphingosine-1-phosphate signaling (S2 Table). The gene discussed is F2; the disease is atherosclerosis.