FMO3 and hyperlipidemia: Over the past 4 years, FMO3 and TMAO have emerged as key components of a complex axis integrating diet and the gut microbiome with atherosclerosis12, 13, 21, 36, and knockdown of FMO3 was recently shown in mouse models of hyperlipidemia to prevent atherosclerosis and improve the metabolic phenotype37.