Interestingly, in a massively parallel, targeted amplicon sequencing of ‘actionable cancer genes’ in ILC post-treatment relapse (that is, recurrence or metastasis), Ross and colleagues [62] reported HER2/ERBB2 genetic alterations in 6 of 22 (27%) cases, including 4 mutations, one gene fusion and one amplification. Here, ERBB2 is linked to cancer.