Of interest, Panc-1 and S2-007 cells, which had been used for the parallelized functional assays with recombinant expression of fluorescence-tagged candidate genes, showed no detectable endogeneous ADRBK1 expression, while the majority of pancreatic cancer cell lines expressed moderate or high levels of ADRBK1 mRNA (Fig 5C). The gene discussed is GRK2; the disease is familial pancreatic carcinoma.