INS and viral infectious disease: As shown in Supplementary Fig. 3b, transplanted Tyk2-deficient (KO) islets to the renal capsule of Tyk2 WT mice did become infected with intraperitoneally injected EMC-D virus and were destroyed without insulin or glucagon (right), compared with noninfected transplanted islets with positive insulin and glucagon staining (left), suggesting that EMC-D virus infection reach systemically target organs and destroyed them when the target organ was susceptible to the viral infection.