Moreover, we could also show that β-cell-specific Tyk2 gene expression using Tyk2 MT mice crossed with MIP-Tyk2 Tg mice (MIP-Tyk2 Tg Tyk2mt/mt) showed resistance to EMC-D virus-induced diabetes (Fig. 6d), similar to MIP-Tyk2 Tg Tyk2 KO mice, confirming the important role of intact Tyk2 gene expression in pancreatic β-cells in the prevention of EMC virus-induced diabetes. This evidence concerns the gene TYK2 and diabetes mellitus.