GLP1R and type 2 diabetes mellitus: Despite these properties, the pharmaco-therapeutic utility of native GLP-1 in T2DM is profoundly limited by its rapid inactivation by the enzyme dipeptidyl dipeptidase-4 (DPP-4), which cleaves 2 amino terminal peptides from GLP-1(7-36) to form the GLP-1(9-36) metabolite [5].