CLDN4 and cancer: On the other hand, several of the genes in the cancer cell compartment are epithelial, such as the cadherin family member desmoglein (DSG2), intracellular junction protein desmoplakin (DSP), the epithelium-specific transcription factors (ELF3 and 5), keratin 7 (KRT7), claudin 4 and 7 (CLDN4 and 7), and integrin beta 8 (ITGB8).