In light of our observations that TRAM-34 and Paxilline inhibited KCa3.1 and KCa1.1 currents, respectively, we tested whether pharmacological inhibition of KCa1.1 and KCa3.1 channels decreases ccRCC cell proliferation in vitro (S2 Fig). This evidence concerns the gene PXN and nonpapillary renal cell carcinoma.