To evaluate whether genetic polymorphisms of the human DPYSL2 gene are associated with schizophrenia, seven SNPs (rs9886448, rs4872449, rs431246, rs2289593, rs327222, rs708621 and rs17666) were selected partially based on the identification of five SNPs (35) and two promoter SNPs of the DPYSL2 that may have affected gene expression in a previously described Japanese population. This evidence concerns the gene DPYSL2 and schizophrenia.