The results of an in silico promoter-binding prediction algorithm (http://www.gene-regulation.com/pub/programs/alibaba2) suggested that SNPs may not affect DPYSL2 gene transcription (data not shown) and, thus, their effects on promoter activity in human SH-SY5Y neuroblastoma cells was examined in vitro. This evidence concerns the gene DPYSL2 and neuroblastoma.