Previous studies have suggested that advanced glycosylation ends (AGEs) triggered by long-term hyperglycemia can stimulate phagocytes to release inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 (2), which may activate osteoclasts and matrix metalloproteinases (MMPs), and lead to the destruction of bone and periodontal tissue (3). The gene discussed is TNF; the disease is Hyperglycemia.