The development of bovine endometritis is associated with very complex signaling processes involving the detection of bacterial components by innate immune cells via Toll-like receptors, the production of the tumor necrosis factor-α (TNF-α) and other proinflammatory cytokines (e.g., interleukins (IL)), and the mobilization of neutrophils followed by the phagocytosis of invading pathogens within the uterine lumen (Beutler et al. 2003; Herath et al. 2009; Sheldon et al. 2009 and Turner et al. 2012). This evidence concerns the gene TNF and endometritis.