TLR2 and neoplasm: A reduction in tumor volume and mass was also observed in α-TLR2 mAb – treated tumor cells even in the absence of zymosan (Supplemental Fig. 2), indicating the presence of a growth-promoting effect from constitutive TLR2 activation, similar to our in vitro studies (Fig. 1C and 2D); however, the antibody-induced reduction in tumor size was not statistically significant.