TLR2 and head and neck squamous cell carcinoma: To determine if TLR2 has a functional role in the growth of HNSCC, we first assessed whether a monoclonal antibody (α-TLR2 mAb, clone T2.5) known to block TLR2 signaling [40], would have any effect on these cell lines in a 3D in vitro organoid model of tumor growth.