Since recent studies showed that activation of KISS1/KISS1R signaling by kisspeptin treatment decreases the motility and invasive capacity of conventional RCC, and overexpression of KISS1 inhibits invasion of RCC cells Caki-1 (40,41), we confirmed the significant upregulation of KISS1 and KISS1R in the 786-0 cells treated with honokiol by qRT-PCR (Fig. 3). The gene discussed is KISS1R; the disease is renal cell carcinoma.