Furthermore, introduction of HLA-G1 or HLA-G5 into HLA-G-negative glioma cells (U87MG) rendered them highly resistant to direct alloreactive lysis, inhibited the alloproliferative response and prevented efficient priming of cytotoxic T cells (24); thus, this gene may contribute to the immune escape in human glioblastoma. Here, HLA-G is linked to glioblastoma.