For example, the collagen-encoding genes (COL1A2, COL3A1, COL4A1 and COL6A2) and integrin-encoding genes (ITGA and ITGB) in pathways 1 and 3, and HLA genes (HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DRB1 and HLA-G) in pathways 3 and 6 may have important roles in the development progress of malignant gliomas. This evidence concerns the gene HLA-DRB1 and malignant glioma.