MDM2 and rhabdomyosarcoma: In our study, we have demonstrated that SRSF1 is capable of regulating the stress-induced alternative splicing of the oncogene MDM2. Indeed, we show that pediatric rhabdomyosarcoma tumors spontaneously expressing MDM2-ALT1 (5) also show elevated levels of SRSF1 compared to matched normal muscle tissue (Figure 8).