TP53 and cervical carcinoma: To investigate a potential mechanistic link between the upregulation of p53 and CADM1 expression in cervical cancer cells, we selected three cell lines, including HEK293T (non-cervical cancer cell line), C33A, and SiHa (cervical cancer cell line), for transfection with a flag-tagged wild-type p53 expression vector (22) or an empty vector.