To analyze the function of the CADM1 gene in HPV-induced cervical carcinogenesis, we treated cells with the demethylating reagent 5-aza-dC to reverse the epigenetic silencing dose-dependently, or constructed and transfected a pCDNA3.1-CADM1 expression vector into each of the cervical cancer cell lines. The gene discussed is CADM1; the disease is cervical cancer.