In this context, the exploration of the mechanisms that control CYP2W1 expression is of paramount importance as it might lead to the development of a novel combined therapy of CRC that would include a tumor-specific induction of CYP2W1 followed by the treatment with CYP2W1-specific prodrugs, increasing thus the number of patients who would benefit from such approach. This evidence concerns the gene CYP2W1 and colorectal carcinoma.