Furthermore, the reduced sensitivity of S-type cells to RG7388 compared to N-type (neuronal) cells is consistent with previous reports of different outcomes of S- versus N-type neuroblastoma cells in response to p53 activation, including Nutlin-3 and MI-63, where N-type cells are more likely to undergo apoptosis in contrast to S-type cells which undergo a G1 cell cycle arrest [18, 21, 23, 24]. This evidence concerns the gene MITF and neuroblastoma.