Within the present panel of p53 wt neuroblastoma cell lines, the highest RG7388 GI50 concentrations (≥ 80 nM) were obtained in MYCN non-amplified cell lines of which 4/5 cell lines (SKNRA, SJNB1, SHEP and GIMEN) comprise predominantly S-type (substrate adherent) cells [21] and 3 cell lines (SHEP, GIMEN and LAN6) have p14ARF aberrations [22]. This evidence concerns the gene MYCN and neuroblastoma.