From the original panel of cell lines assessed above, 8 p53 wt neuroblastoma cell lines (non-MYCN amplified SHSY5Y & SKNRA; MYCN amplified IMR32 & LAN5; MDM2 and MYCN co-amplified NGP & NB1691; p14ARF methylated Per-108 & GIMEN) and Tet21N cells were analysed for cell cycle phase distribution and induction of apoptosis in response to RG7388 (Figure 2 and Supplementary Table 1). The gene discussed is MDM2; the disease is neuroblastoma.